Chaste - Cancer Heart And Soft Tissue Environment
Chaste is a computational biology simulation package. It provides a cardiac simulation package which provides a way to use CellML electrophysiology models in tissue simulations. The cardiac code is suitable for high performance computing on large
... [More] supercomputers.
The cell-based side of the code provides a variety of agent-based models (cellular automata, cell-centre-based (on and off mesh), cell vertex, cellular Potts models) for use in biological settings where cells divide and die according to other models.
For details please see the recent overview paper in PLoS Computational Biology www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002970 [Less]
Provides a user-friendly web interface to the Functional Curation system for evaluating and comparing mathematical models of biological systems under a range of experimental scenarios.
ApPredict is a free open source program for prediction of action potential changes under drug-block of ion channels. The ion channel block is modelled as conductance block, and it can be used with a number of action potential models (specified using CellML), different pacing rates.
Blockade of
... [More] the following ion channels can be included: IKr (hERG), IKs (KCNQ1), ICaL (CaV1.2), INa (NaV1.5), Ito (Kv4.3), IK1 (KCNN4). [Less]
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